Posted by: Indonesian Children | May 2, 2010

In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychologic stress

 

 Maes et al 2000 – Serum PUFA levels predict proinflammatory responses to psychological stress  

In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychologic stress

Maes, M., Armand C., Bosmans, E., Lin, A., Neels, H. (2000) Biological Psychiatry 47(10) 910-920
Web URL: Licensed users of Biological Psychiatry online (via Science Driect) can access this paper here

Abstract: BACKGROUND: Psychologic stress in humans induces the production of proinflammatory cytokines, such as interferon (IFN- ), tumor necrosis factor (TNF- ), and interleukin-6 (IL-6), and that of the negative immunoregulatory cytokine, IL-10. An imbalance of omega-6 to omega-3 polyunsaturated fatty acids (PUFAs) in the peripheral blood causes an overproduction of proinflammatory cytokines. The omega-3 PUFAs reduce the production of proinflammatory cytokines. METHODS: This study examines whether an imbalance in omega-6 to omega-3 PUFAs in human blood predicts a greater production of proinflammatory cytokines in response to psychologic stress. Twenty-seven university students had serum sampled a few weeks before and after as well as 1 day before a difficult oral examination. We determined the omega-6 and omega-3 fractions in serum phospholipids as well as the ex vivo production of IFN- , TNF- , IL-6, IL-10, and IL-5 by diluted whole blood stimulated with polyclonal activators. RESULTS: Academic examination stress significantly increased the ex vivo, stimulated production of IFN- , TNF- and IL-10, and the IFN- /IL-5 production ratio. Subjects with lower serum omega-3 PUFA levels or with a higher omega-6/ omega-3 ratio had significantly greater stress-induced TNF- and IFN- responses than subjects with higher serum omega-3 PUFAs and a lower omega-6/ omega-3 ratio, respectively. Subjects with lower serum omega-3 PUFA levels or with a higher omega-6/ omega-3 ratio had a significantly higher stress-induced increase in the IFN- /IL-5 ratio than the remaining subjects. CONCLUSIONS: Psychologic stress induces a Th-1–like or proinflammatory response in some subjects. An imbalance in the omega-6 to omega-3 PUFA ratio appears to predispose humans toward an exaggerated Th-1–like response and an increased production of monocytic cytokines, such as TNF- , in response to psychologic stress. The results suggest that increased omega-3 PUFA levels may attenuate the proinflammatory response to psychologic stress.

 

Supported by

children’s ALLERGY Center   JL TAMAN BENDUNGAN ASAHAN 5 JAKARTA PUSAT, JAKARTA INDONESIA 10210

PHONE : (021) 70081995 – 5703646

htpp://www.childrenallergyclinic.wordpress.com/ 

 

Clinical and Editor in Chief :

WIDODO JUDARWANTO 

email : judarwanto@gmail.com,

 

 

Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider. 

 

 

Copyright © 2010, Children Allergy Center Information Education Network. All rights reserved


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Categories

%d bloggers like this: