Posted by: Indonesian Children | May 3, 2010

The role of mast cells in migraine pathophysiology

Review

The role of mast cells in migraine pathophysiology

Brain Research Reviews
Volume 49, Issue 1, July 2005, Pages 65-76

 

Theoharis C. Theoharides, , Jill Donelan, Kristiana Kandere-Grzybowska1 and Aphrodite Konstantinidou2
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts-New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA
Accepted 30 November 2004.  Available online 12 February 2005.

Abstract

Mast cells are critical players in allergic reactions, but they have also been shown to be important in immunity and recently also in inflammatory diseases, especially asthma. Migraines are episodic, typically unilateral, throbbing headaches that occur more frequently in patients with allergy and asthma implying involvement of meningeal and/or brain mast cells. These mast cells are located perivascularly, in close association with neurons especially in the dura, where they can be activated following trigeminal nerve, as well as cervical or sphenopalatine ganglion stimulation. Neuropeptides such as calcitonin gene-related peptide (CGRP), hemokinin A, neurotensin (NT), pituitary adenylate cyclase activating peptide (PACAP), and substance P (SP) activate mast cells leading to secretion of vasoactive, pro-inflammatory, and neurosensitizing mediators, thereby contributing to migraine pathogenesis. Brain mast cells can also secrete pro-inflammatory and vasodilatory molecules such as interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF), selectively in response to corticotropin-releasing hormone (CRH), a mediator of stress which is known to precipitate or exacerbate migraines. A better understanding of brain mast cell activation in migraines would be useful and could lead to several points of prophylactic intervention.

 

Keywords: Allergy; CRH; Histamine; Mast cells; Migraines; Stress

Abbreviations: BBB, blood–brain barrier; CGRP, calcitonin-gene related peptide; CRH, corticotropin-releasing hormone; IL-6, interleukin-6; NGF, nerve growth factor; NO, nitric oxide; NT, neurotensin; PACAP, pituitary adenylate cyclase activating peptide; SP, substance P; TNF-α, tumor necrosis factor-alpha; VIP, vasoactive intestinal peptide; Ucn, urocortin; VEGF, vascular endothelial growth factor
Neuroscience classification codes: Neural-immune interactions, Brain

 

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children’s ALLERGY Center   JL TAMAN BENDUNGAN ASAHAN 5 JAKARTA PUSAT, JAKARTA INDONESIA 10210

PHONE : (021) 70081995 – 5703646

htpp://www.childrenallergyclinic.wordpress.com/ 

 

Clinical and Editor in Chief :

WIDODO JUDARWANTO 

email : judarwanto@gmail.com,

 

 

Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider. 

 

 

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