Posted by: Indonesian Children | August 26, 2010

Reference and Bibliography Relation Atopic Dermatitis and Food Allergy

Reference and Bibliography Relation Atopic Dermatitis and Food Allergy

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects between 10% and 12% of the pediatric population. There is an increasing body of clinical and laboratory evidence suggesting that food hypersensitivity plays a pathogenic role in AD in a subset of patients. The skin is one of the target organs that is most often involved in food hypersensitivity reactions. Clinical manifestations of food hypersensitivity in the skin range from symptoms of atopic dermatitis, to urticaria and angioedema, dermatitis herpetiformis, and a masquerader of food allergy, Frey’s syndrome. All present with typical skin manifestations of their food-allergic reactions. For most skin manifestations provoked by food hypersensitivity, pruritus is a hallmark of the disease. With this review, the above diseases are discussed, as well as the laboratory and clinical investigations that demonstrate how food hypersensitivity plays a pathogenic role in the skin manifestations of allergic reactions.
However, the prevalence of clinically relevant food hypersensitivity among children with AD remains an unanswered question. Sampson and McCaskill found that ~60% of a highly selected group of pediatric patients with AD evaluated by double-blind, placebo-controlled food challenge (DBPCFC) experienced a positive reaction to food. Burks and colleagues used DBPCFC to evaluate a group of 46 children with moderate to severe AD identified in an allergy-treatment clinic (31 patients) and a dermatology clinic (15 patients). Fifteen patients (33%) were determined to have clinically relevant food allergy, but the study has been criticized because a majority of the patients were recruited from the allergy clinic, introducing some selection bias.
 
 Reference and Bibliography Relation Atopic Dermatitis and Food Allergy
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