Recommendations for appropriate sublingual immunotherapy clinical trials

Reviews and feature article

References and further reading may be available for this article. To view references and further reading you must purchase this article.

Thomas B. Casale MD^{a, ,} , G. Walter Canonica MD^b, Jean Bousquet MD^c, Linda Cox MD^d, Richard Lockey MD^e, Harold S. Nelson MD^f and Giovanni Passalacqua MD^b

^aCreighton University, Omaha, Neb

^bUniversity of Genoa, Genoa, Italy

^cHopital Arnaud de Villeneuve, Montpellier, and Institut National de la Santi et de la Recherche Midicale U780, Montpellier, France

^dNova Southeastern University School of Osteopathic Medicine, Davie, Fla

^eUniversity of South Florida, Tampa, Fla

^fNational Jewish Health, Denver, Colo

Received 3 April 2009; 

revised 20 July 2009; 

accepted 31 July 2009. 

Available online 19 September 2009.

 

Sublingual immunotherapy is gaining widespread attention as a viable alternative to subcutaneous immunotherapy for the treatment of allergic rhinoconjunctivitis. In addition, sublingual immunotherapy has been studied in other allergic disorders including asthma. However, a review of published studies indicates that there are deficiencies and considerable heterogeneity in both design and data interpretation of sublingual immunotherapy studies. These deficiencies have made it somewhat difficult to assess the appropriate place of sublingual immunotherapy in guidelines for the therapy of allergic diseases. Moreover, several unpublished oral and sublingual immunotherapy studies in the United States failed to meet primary endpoints. This article reviews data from sublingual immunotherapy trials and makes recommendations about appropriate designs of future sublingual immunotherapy studies. It is hoped that these recommendations will result in more adequately designed sublingual immunotherapy trials to facilitate the appropriate placement of this therapy to treat patients with allergic rhinoconjunctivitis and other allergic diseases.

Key words: Immunotherapy; sublingual immunotherapy; subcutaneous immunotherapy; allergic rhinitis; allergic conjunctivitis; allergic asthma

Abbreviations: AE, Adverse event; PCT, Placebo-controlled superiority trial; QOL, Quality of life; SCIT, Subcutaneous immunotherapy; SLIT, Sublingual immunotherapy

 

source :wao

Supported  by

Widodo judarwanto, pediatrician

Clinic For Children  http://childrenclinic.wordpress.com

Children Allergy Center Online   www.childrenallergyclinic.wordpress.com/  

Picky Eaters Clinic, Klinik Kesulitan makan Pada Anak  www.mypickyeaters.wordpress.com/  

Office : JL Taman Bendungan Asahan 5  Jakarta Pusat  Phone : (021) 70081995 – 5703646email :  judarwanto@gmail.com,

Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.  

        

Copyright © 2010, Children Allergy Center  Information Education Network. All rights reserved