Posted by: Indonesian Children | November 9, 2010

Recommendations for appropriate sublingual immunotherapy clinical trials

Reviews and feature article

Recommendations for appropriate sublingual immunotherapy clinical trials

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Thomas B. Casale MDa, Corresponding Author Contact Information, E-mail The Corresponding Author, G. Walter Canonica MDb, Jean Bousquet MDc, Linda Cox MDd, Richard Lockey MDe, Harold S. Nelson MDf and Giovanni Passalacqua MDb

aCreighton University, Omaha, Neb

bUniversity of Genoa, Genoa, Italy

cHopital Arnaud de Villeneuve, Montpellier, and Institut National de la Santi et de la Recherche Midicale U780, Montpellier, France

dNova Southeastern University School of Osteopathic Medicine, Davie, Fla

eUniversity of South Florida, Tampa, Fla

fNational Jewish Health, Denver, Colo

Received 3 April 2009; 

revised 20 July 2009; 

accepted 31 July 2009. 

Available online 19 September 2009.


Sublingual immunotherapy is gaining widespread attention as a viable alternative to subcutaneous immunotherapy for the treatment of allergic rhinoconjunctivitis. In addition, sublingual immunotherapy has been studied in other allergic disorders including asthma. However, a review of published studies indicates that there are deficiencies and considerable heterogeneity in both design and data interpretation of sublingual immunotherapy studies. These deficiencies have made it somewhat difficult to assess the appropriate place of sublingual immunotherapy in guidelines for the therapy of allergic diseases. Moreover, several unpublished oral and sublingual immunotherapy studies in the United States failed to meet primary endpoints. This article reviews data from sublingual immunotherapy trials and makes recommendations about appropriate designs of future sublingual immunotherapy studies. It is hoped that these recommendations will result in more adequately designed sublingual immunotherapy trials to facilitate the appropriate placement of this therapy to treat patients with allergic rhinoconjunctivitis and other allergic diseases.

Key words: Immunotherapy; sublingual immunotherapy; subcutaneous immunotherapy; allergic rhinitis; allergic conjunctivitis; allergic asthma

Abbreviations: AE, Adverse event; PCT, Placebo-controlled superiority trial; QOL, Quality of life; SCIT, Subcutaneous immunotherapy; SLIT, Sublingual immunotherapy


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